Ultimately as clinicians we all want to make a difference to our patients, and that comes down to therapy. Understanding whether a therapy is effective or not and if so to what extent is essential when we decide on treatment.
In this section we have a look at key parts of therapeutic studies that will help us better appraise a therapeutic paper. The whole study should be designed around making the effect of the intervention as clear as possible.
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Once you’ve listened help consolidate the topics covered with the questions below.
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Randomisation reduces allocation bias?
Allocation concealment is mandatory if a study is to utilise randomisation?
Blinding can prevent reporter and observer bias?
An intention to treat analysis is the same as a per-protocol analysis?
The proportion of patients followed up is irrelevant if randomisation took place?
Composite outcomes are easier to interpret than single primary outcomes?