Critical Appraisal of a Diagnostic Study
Its now time to pull all the theory together and critically appraise a diagnostic study.
In this podcast we review the The ADJUST-PE Study which is a free open access paper. We run through the critical appraisal with the CASP diagnostic checklist.
Have a read of the paper, run through the checklist, have a listen to the podcast and then to consolidate answer the questions below.
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Question 1 of 6
1. Question
The study describes the population having a prevalence of PE of 19%. Prevalence relates to the number of new cases occurring in a set time period?
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Question 2 of 6
2. Question
The prevalence of PE being higher in the study compared to other populations means that the rate of false negatives is likely to be lower?
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Question 3 of 6
3. Question
With regards to quality of data within this study, the prospective nature of the study makes the data more likely to be accurate.
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Question 4 of 6
4. Question
Raising the cut-off for a positive d-dimer with an age adjusted level is done in order to raise it's sensitivity?
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Question 5 of 6
5. Question
Making the study multi centre and multinational potentially increases the internal validity of the study?
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Question 6 of 6
6. Question
The 3 month failure rate for patients with PE ruled out between 500 µg/L but below the age-adjusted cutoff was 1 of 331 patients. This was expressed as 0.3% [95% CI, 0.1%-1.7%]. The relatively narrow confidence intervals reflect a good accuracy of the result?
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